Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis

Figure 6 fgl2^Tg Teff do not induce colitis. A: Histopathology. Rag1^-/- mice that received fgl2^+/+ Teff had histologic evidence of severe colitis with dense CD3⁺ T cell infiltrates, edema, crypt and goblet cell loss and abscess formation. Colons from mice that received fgl2^Tg Teff were near normal. H&E; Original magnification × 100; B: Extent of disease in the colon was confirmed by pathologic scoring. Three sections of the colon were scored as described in the methods. Data are the mean ± SD; C: Immunohistochemistry of CD3⁺ staining in the colon (left column) or MLN (right column) showing repopulation of MLN in mice that received either fgl2^Tg or fgl2^+/+ Teff. Dense infiltrates of CD3⁺ cells were only seen in the colons of mice that received fgl2^+/+ Teff and not fgl2^Tg Teff. Original magnification × 100. Data represent n = 3 mice per group (^bP < 0.01, ^eP < 0.001). MLN: Mesenteric lymph nodes; Teff: Effector T cells.