Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients

Table 3 Univariate and multivariate logistic regression analysis of risk factors of significant necroinflammation and fibrosis

	Significant necroinflammation				Significant fibrosis
	Univariate		Multivariate		Univariate		Multivariate
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Age (yr)	0.994 (0.949, 1.042)	0.812			1.003 (0.968, 1.040)	0.120
Male	1.351 (0.530, 3.440)	0.529			1.346 (0.656, 2.760)	0.418
HBV-DNA (logIU/mL)	1.249 (0.978, 1.595)	0.075			1.078 (0.910, 1.276)	0.385
WBC (109/mL)	0.907 (0.648, 1.269)	0.569			0.611 (0.359, 1.039)	0.069
PLT (109/mL)	0.990 (0.980, 0.999)	0.03			0.692 (0.646, 0.709)	0.003	0.688 (0.641, 0.723)	0.008
ALT (U/L)	1.081 (1.020, 1.147)	0.009			1.059 (0.985,1.139)	0.121
AST (U/L)	1.590 (1.502, 1.651)	0.0002	1.682 (1.613, 1.704)	0.007	1.091 (1.006, 1.185)	0.036
ALP (U/L)	1.018 (0.994, 1.042)	0.139			1.051 (1.015, 1.089)	0.006
GGT (U/L)	1.021 (0.993, 1.050)	0.151			1.524 (1.491, 1.587)	0.007	1.453 (1.406, 1.511)	0.036
TB (g/L)	0.988 (0.921, 1.059)	0.723			1.025 (0.945, 1.112)	0.547
PT (s)	1.683 (0.941, 3.009)	0.079			2.022 (1.012, 4.042)	0.083
TT (s)	1.235 (0.945, 1.615)	0.122			1.294 (0.948, 1.768)	0.105
A/G ratio	2.053 (0.570, 7.393)	0.271			0.580 (0.099, 3.394)	0.546
Cr (μmol/L)	0.974 (0.941, 1.009)	0.143			1.000 (0.957, 1.046)	0.997
TBA (μmol/L)	1.063 (0.998, 1.131)	0.057			1.065 (1.001, 1.133)	0.048
GLB (g/L)	0.953 (0.862, 1.053)	0.345			1.001 (0.877, 1.143)	0.986
ALB (g/L)	0.931 (0.836, 1.036)	0.191			0.923 (0.805, 1.058)	0.250

A/G ratio: Albumin to globulin (A/G) ratio; ALB: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate transaminase; Cr: Creatinine; GGT: Gamma-glutamyl transpeptidase; GLB: Globulin; PT: Prothrombin time; TB: Total bilirubin; TBA: Total bile acid; TT: Thrombin time.