Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients

Table 2 Demographic and clinical characteristics of carriers with and without significant liver changes

	Significant necroinflammation (n = 42)	No significant necroinflammation (n = 113)	P value	Significant fibrosis (n = 24)	No significant fibrosis (n = 131)	P value
Age (yr)	40.0 ± 9.3	39.7 ± 10.1	0.854	41.3 ± 10.3	39.5 ± 9.8	0.416
Male, n (%)	13	79	0.417	20	23	0.505
HBV DNA (logIU/mL)	6.0 ± 2.0	5.7 ± 2.2	0.368	5.6 ± 2.0	5.8 ± 2.1	0.733
WBC (109/mL)	6.2 ± 5.7	5.7 ± 1.4	0.560	4.9 ± 1.2	6.0 ± 3.3	0.117
PLT (109/mL)	170.2 ± 58.4	197.5 ± 63.2	0.016	150.3 ± 51.1	197.4 ± 62.3	0.001
ALT (U/L)	29.6 ± 8.8	24.6 ± 8.3	0.001	29.7 ± 8.0	25.3 ± 8.6	0.116
AST (U/L)	27.5 ± 6.0	23.6 ± 6.0	0.004	27.8 ± 6.4	24.1 ± 6.6	0.012
ALP (U/L)	70.4 ± 25.0	67.2 ± 17.9	0.463	78.7 ± 29.4	66.1 ± 17.3	0.004
GGT (U/L)	25.8 ± 19.4	20.3 ± 12.1	0.423	33.9 ± 25.4	19.6 ± 10.3	0.000
TB (g/L)	14.1 ± 6.9	13.4 ± 6.7	0.538	16.0 ± 7.2	13.2 ± 6.6	0.057
PT (s)	11.6 ± 1.0	11.3 ± 1.2	0.100	11.7 ± 1.0	11.3 ± 1.2	0.152
TT (s)	19.4 ± 1.7	19.0 ± 1.6	0.235	19.2 ± 1.8	19.1 ± 1.6	0.776
A/G ratio	1.8 ± 0.4	1.7 ± 0.4	0.173	1.7 ± 0.3	1.8 ± 0.4	0.700
Cr (μmol/L)	66.7 ± 14.6	71.5 ± 14.4	0.070	71.8 ± 14.2	69.9 ± 14.7	0.557
TBA (μmol/L)	9.0 ± 8.1	8.7 ± 15.7	0.900	16.8 ± 30.5	7.3 ± 7.4	0.002
GLB (g/L)	26.5 ± 4.3	27.5 ± 4.2	0.183	27.3 ± 3.9	27.2 ± 4.3	0.915
ALB (g/L)	45.1 ± 3.4	45.8 ± 4.2	0.335	44.2 ± 3.5	45.9 ± 4.1	0.058

A/G ratio: Albumin to globulin (A/G) ratio; ALB: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate transaminase; Cr: Creatinine; GGT: Gamma-glutamyl transpeptidase; GLB: Globulin; PT: Prothrombin time; TB: Total bilirubin; TBA: Total bile acid; TT: Thrombin time.