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©The Author(s) 2017.
World J Gastroenterol. Apr 21, 2017; 23(15): 2771-2784
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2771
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2771
Table 5 Urinary metabolites differentially expressed in patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
No. | Metabolites | VIP-value (OPLS-DA) | P value (t-test) | Fold change |
ESI+ | ||||
1 | L-Carnitine | 1.253 | 0.067 | -0.727 |
2 | L-Dopa | 0.952 | 0.092 | 0.234 |
3 | Acetylcarnitine | 1.181 | 0.094 | -0.698 |
4 | L-Histidine | 1.229 | 0.081 | -1.339 |
5 | Pyroglutamic acid | 1.541 | 0.021 | 0.143 |
6 | 3-Methylxanthine | 2.403 | 0.002 | -1.981 |
7 | α-D-Glucose | 1.739 | 0.013 | -1.376 |
8 | 5-Hydroxyferulate | 0.895 | 0.058 | -0.266 |
9 | 2-Oxosuberate | 0.850 | 0.073 | -0.315 |
10 | p-Hydroxyphenylacetic acid | 1.354 | 0.095 | 0.398 |
11 | 3-Indoleacetic Acid | 0.915 | 0.052 | -0.378 |
12 | β-Estradiol | 1.883 | 0.002 | -0.635 |
13 | Phosphorylcholine | 1.731 | 0.032 | 0.716 |
14 | 17α-Hydroxypregnenolone | 0.854 | 0.087 | -0.281 |
15 | Deoxycorticosterone | 0.865 | 0.093 | -0.312 |
16 | Progesterone | 0.866 | 0.084 | -0.301 |
ESI- | ||||
17 | 2-Keto-glutaramic acid | 1.653 | 0.027 | 0.210 |
18 | cAMP | 1.659 | 0.041 | 0.196 |
19 | 7-Methylxanthine | 1.595 | 0.036 | -0.925 |
20 | (S)-(-)-2-Hydroxyisocaproic acid | 1.344 | 0.089 | -0.250 |
21 | Gluconic acid | 1.638 | 0.025 | -1.111 |
22 | N-Acetylproline | 1.865 | 0.021 | 0.399 |
23 | Acetyl-DL-valine | 1.636 | 0.053 | 0.284 |
24 | Pyridoxal phosphate | 1.490 | 0.050 | -0.990 |
25 | N-Acetyl-DL-tryptophan | 1.440 | 0.059 | -0.951 |
26 | 2-Keto-D-gluconic acid | 1.258 | 0.088 | -0.340 |
27 | D-(+)-3-Phenyllactic acid | 2.021 | 0.017 | -1.621 |
28 | Indoleactic acid | 1.495 | 0.051 | 0.832 |
29 | 3-Hydroxy-sebacic acid | 1.270 | 0.092 | -0.292 |
30 | Sebacic acid | 1.847 | 0.024 | 0.420 |
31 | Deoxyguanosine | 1.548 |
- Citation: Dong S, Zhan ZY, Cao HY, Wu C, Bian YQ, Li JY, Cheng GH, Liu P, Sun MY. Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(15): 2771-2784
- URL: https://www.wjgnet.com/1007-9327/full/v23/i15/2771.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i15.2771