Review
Copyright ©The Author(s) 2017.
World J Gastroenterol. Apr 21, 2017; 23(15): 2651-2659
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2651
Table 2 Heavy alcohol consumption and risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
Author (year)CountryDesignnFollow-up, yearsAlcohol intakeRelative risk for HCCRef.
Donato (2002)ItalyCase-control study464 with HCC (including 92 with HBV) vs 824 controls (including 44 with HBV)NA≥ 60 g/d2.13[30]
Lin (2013)TaiwanRetrospective cohort study632 cirrhotics with HBV and alcohol vs 132 cirrhotics with HBV alone2.9-5.2≥ 80 g/d for ≥ 5 yr1.33[31]
Ikeda (1998)JapanProspective cohort study610 with HBV4. 1500 kg (cumulative)8.37[32]