Berberine displays antitumor activity in esophageal cancer cells in vitro

Figure 2 Berberine treatment induced cell cycle arrest in G2/M phase. A: Flow cytometry analysis of proliferating KYSE-70 cells at 48 h after administration of 50 μmol/L berberine; B: Relative percentages of berberine-treated cells to control cells in different cell cycle phases are shown as the mean ± SE of three independent experiments. ^aP < 0.05 vs controls; C: Protein expression level of p21 in KYSE-70 cells was examined after berberine administration at 6, 12 and 24 h.