PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma

Table 3 PIK3CA mutations and clinicopathological characteristics in Northwest Chinese esophageal squamous cell carcinoma patients n (%)

Clinical, epidemiologic, or pathologic feature	Total, n	PIK3CA		P value
		Mutant	Wild-type
All cases	210	48	162
Sex				0.4756
Male	137 (65.3)	34 (70.8)	123 (75.9)
Female	73 (34.7)	14 (29.2)	39 (24.1)
Tobacco use				0.2684
Yes	149 (71.0)	31 (64.6)	118 (72.9)
No	61 (29.0)	17 (35.4)	44 (28.1)
Alcohol use				0.3778
Yes	175 (83.3)	38 (79.2)	137 (84.6)
No	35 (16.7)	10 (20.8)	25 (15.4)
Preoperative treatment				0.8467
Yes	28 (13.3)	6 (12.5)	22 (13.6)
No	182 (86.7)	42 (87.5)	140 (86.4)
Tumor location				0.9651
Upper thoracic	20 (9.5)	5 (10.4)	15 (9.2)
Middle thoracic	109 (51.9)	25 (52.1)	84 (51.9)
Lower thoracic	81 (38.6)	18 (37.5)	63 (38.9)
Stage				0.1641
IA	16 (7.6)	3 (6.3)	13 (8.0)
IB	20 (9.5)	5 (10.4)	15 (9.3)
IIA	28 (13.3)	11 (22.9)	17 (10.5)
IIB	44 (21.0)	10 (20.8)	34 (21.0)
IIIA	49 (23.3)	12 (25.0)	37 (22.8)
IIIB	23 (11.0)	1 (2.1)	22 (13.6)
IIIC	30 (14.3)	6 (12.5)	24 (14.8)
Lymph node metastasis				0.2663
Yes	121 (57.6)	31 (64.6)	90 (55.6)
No	89 (42.4)	17 (35.4)	72 (44.4)
Local recurrence				0.7368
Yes	43 (20.5)	9 (18.8)	34 (21.0)
No	167 (79.5)	39 (81.2)	128 (79.0)
Prognosis				0.0885
Dead	88 (41.9)	15 (31.3)	73 (45.1)
Survived	122 (58.1)	33 (68.7)	89 (54.9)