Clinical characteristics of peptic ulcer perforation in Korea

Table 2 Comparison of clinical characteristics between patients with perforated peptic ulcer who were tested for Helicobacter pylori infection or not n (%)

Variables	Total (n = 396)			Gastric ulcer (n = 173)			Duodenal ulcer (n = 223)
	Patients who were testedfor H. pylori infection(n = 174)	Patients who were not tested for H. pylori infection(n = 222)	P value	Patients who were testedfor H. pylori infection(n = 72)	Patients who were not tested for H. pylori infection(n = 101)	P value	Patients who were testedfor H. pylori infection(n = 102)	Patients who were not tested for H. pylori infection(n = 121)	P value
Sex (men)	151 (86.8)	186 (83.8)	0.480	60 (83.3)	85 (84.2)	> 0.99	91 (89.2)	101 (83.5)	0.25
Age (yr)	47.6 ± 16.8	53.0 ± 19.1	0.003	47.5 ± 18.3	54.1± 19.1	0.02	47.6 ± 15.7	52.2 ± 19.1	0.05
< 60	133 (76.4)	142 (64.0)	0.008	56 (77.8)	61 (60.4)	0.02	77 (75.5)	81 (66.9)	0.18
≥ 60	41 (23.6)	80 (36.0)		16 (22.2)	40 (39.6)		25 (24.5)	40 (33.1)
BMI (kg/m2)	22.0 ± 3.1	21.5 ± 2.8	0.150	21.5 ± 3.1	21.4 ± 2.7	0.83	22.3 ± 3.0	21.6 ± 3.00	0.10
Alcohol drinking	87 (50.0)	100 (45.0)	0.360	33 (45.8)	43 (42.6)	0.76	54 (52.9)	57 (47.1)	0.42
Current smoking	97 (55.7)	124 (55.9)	> 0.99	39 (54.2)	59 (58.4)	0.64	58 (56.9)	65 (53.7)	0.69
Both alcohol consumption and smoking	69 (39.7)	85 (38.3)	0.840	24 (33.3)	36 (35.6)	0.87	45 (44.1)	49 (40.5)	0.59
Previous ulcer history	30 (17.2)	24 (10.8)	0.08	14 (19.4)	13 (12.9)	0.29	16 (15.7)	11 (9.1)	0.15
Comorbidity	44 (25.3)	79 (35.6)	0.03	21 (29.2)	40 (39.6)	0.2	23 (22.5)	39 (32.2)	0.13
HTN	27 (61.4)	55 (69.6)	0.43	14 (66.7)	24 (60.0)	0.78	13 (56.5)	31 (79.5)	0.08
DM	13 (29.5)	28 (35.4)	0.55	5 (23.8)	13 (32.5)	0.56	8 (34.8)	15 (38.5)	> 0.99
Cardiovascular disease	6 (13.6)	15 (19.0)	0.62	3 (14.3)	7 (17.5)	0.53	3 (13.0)	8 (20.5)	0.35
Chronic liver disease	5 (11.4)	8 (10.1)	0.53	1 (4.8)	7 (17.5)	0.24	4 (17.4)	1 (2.6)	0.06
Malignancy	0 (0.0)	9 (11.4)	0.02	0 (0.0)	6 (15.0)	0.07	0 (0.0)	3 (7.7)	0.24
Chronic kidney injury	3 (6.8)	3 (3.8)	0.17	2 (9.5)	2 (5.0)	0.43	1 (4.3)	1 (2.6)	0.61
Pulmonary disease	0 (0.0)	4 (5.1)	0.37	0 (0.0)	3 (7.5)	0.28	0 (0.0)	1 (2.6)	0.63
Infectious disease	1 (2.3)	2 (2.5)	0.71	1 (4.8)	1 (2.5)	0.57	0 (0.0)	1 (2.6)	0.63
Current medication
NSAIDs	21 (12.1)	23 (10.4)	0.63	9 (12.7)	11 (11.0)	0.81	12 (11.8)	12 (9.9)	0.67
Steroid	2 (1.2)	6 (2.7)	0.24	1 (1.4)	4 (4.0)	0.31	1 (1.0)	2 (1.7)	0.56
Proton pump inhibitor	7 (4.0)	12 (5.4)	0.64	3 (4.2)	8 (7.9)	0.26	4 (3.9)	4 (3.3)	0.54
H2-blocker	4 (2.3)	8 (3.6)	0.56	3 (4.2)	2 (2.0)	0.34	1 (1.0)	6 (5.0)	0.09

PPU: Perforated peptic ulcer; BMI: Body mass index; HTN: Hypertension; DM: Diabetes mellitus; NSAIDs: Non-steroidal anti-inflammatory drugs; H. pylori: Helicobacter pylori.