Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis

Table 1 Summary of a case series of eosinophilic gastrointestinal disorders in the esophagus¹ (n = 10)

Diagnosis2	EoE					sEoE	EoEM
	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7	Case 8	Case 9	Case 10
Epithelium/sub-3	44/2	40/3	50/4	27/-	46/0	3/35	0/0	0/-	0/5 (EMR)	0/27 (EMR)
Muscle layer4							36	30	73	48
Age	31	54	54	35	35	75	43	31	75	67
M/F	M	F	M	M	M	M	M	M	M	M
Allergy history	House dust	Milk	No	No	No	No	No	No	No	Rabbit
Symptoms5	D,F	C,D,F	C,D	D	D	D	C,D	C,D	D	C,D
Endoscopic findings6	+/+/+/-	+/+/-/-	+/+/+/-	+/+/-/-	+/+/-/-	-/-/-/+	-/-/-/+	-/-/-/+	-/-/-/+	-/-/-/+
Manometry7	FP	FP	FP	FP	Normal	FP	JE	NE	JE	JE
Serum IgE (IU/mL)	314.0	33.5	33.3	39.0	39.0	678.0	194.0	368.0	192.0	545.0
Histological findings8	+/+/-	+/+/-	+/+/-	+/+/-	+/+/-	-/-/+	-/-/+	-/-/+	-/-/+	-/-/+

¹Esophageal eosinophilia: defined as ≥ 15 eosinophils/high-power field (eos/hpf) in any layer of the epithelium, sub-epithelium, or muscularis propria;

²EoE: Eosinophilic esophagitis, sEoE: Subepithelial eosinophilic esophagitis, EoEM: Eosinophilic esophageal myositis;

³Eos/hpf in epithelium/subepithelium, separately, -: No data;

⁴Eos/hpf in the esophageal muscle layer by peroral esophageal muscle biopsy;

⁵Symptoms; C: Chest pain, D: Dysphagia, F: Food impaction;

⁶Endoscopic findings: Presence/absence (+/-, respectively) of longitudinal furrows/white plaques/fixed rings/luminal compression;

⁷Manometry findings: FP: Failed peristalsis; JE: Jackhammer esophagus; NE: Nutcracker esophagus;

⁸Histological findings of the epithelium: Presence/absence (+/-, respectively) of dilated intercellular space/downward papillae elongation/basal cell layer destruction. EMR: Endoscopic mucosal resection; IgE: Immunoglobulin E.