Cullin 4A is associated with epithelial to mesenchymal transition and poor prognosis in perihilar cholangiocarcinoma

Table 1 Correlation between cullin 4A expression and clinicopathologic parameters of perihilar cholangiocarcinoma

Parameter	n	CUL4A IHC score	P value
Age (yr)			0.902
< 65	54	4.07 ± 2.46
≥ 65	24	3.99 ± 2.47
Gender			0.606
Male	45	3.92 ± 2.34
Female	33	4.21 ± 2.62
Tumour size (cm)			0.330
< 3	36	3.75 ± 2.55
≥ 3	42	4.30 ± 2.36
Differentiation grade			< 0.001
Well + moderate	66	3.56 ± 2.30
Poor + undifferentiated	12	6.68 ± 1.24
T stage			0.001
T1 + T2	63	3.62 ± 2.34
T3 + T4	15	5.81 ± 2.12
N stage			< 0.001
N0	64	3.35 ± 2.08
N1 + N2	14	7.21 ± 1.13
M stage			0.980
M0	76	4.04 ± 2.46
M1	2	4.00 ± 2.83
TNM stage			< 0.001
I + II	54	3.14 ± 2.03
III + IV	24	6.08 ± 2.07

IHC: Immunohistochemistry; CUL4A: Cullin 4A.