Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models

Figure 8 Effects of B. infantis CGMCC313-2 on cytokines in serum and bronchoalveolar lavage fluid. IL-4, IL-10, and IL-13 in serum and BALF were determined in BLG-induced food allergy mice and OVA-induced allergic asthma mice, respectively. A: Serum IL-4 in the prevention (pre; Group 3) group; B: serum IL-13 in the prevention (pre; Group 3) and pre-treatment (tre; Group 4) groups were significantly decreased compared with the positive control (PC; Group 2) group; C: There was no significant difference in IL-10 between the positive control group (PC; Group 2), prevention group (pre; Group 3), and pre-treatment (tre; Group 4), which was significantly decreased when compared with the normal control (NC; Group 1) group; D: The concentrations of BALF IL-4 and (E) BALF IL-13 were significantly decreased in the prevention (pre; Group 3) group and the pre-treatment (tre; Group 4) group treated with B. infantis CGMCC313-2. The statistical differences are represented as follows: ^aP < 0.05; ^bP < 0.01, and ^cP < 0.001.