Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models

Figure 3 Effect of B. infantis CGMCC313-2 on the reversal of IgE and IgG1 in ovalbumin-induced asthma and β-lactoglobulin-induced food allergy mouse models. A and B: There were significant increases in OVA-specific IgE and IgG1 expression in the positive control (PC; Group 2) group compared with the normal control (NC; Group 1) group in the allergic asthma mouse model. The prevention (pre; Group 3) and pre-treatment (tre; Group 4) groups following B. infantis CGMCC313-2 administration showed decreased expression; C: A significant increase in total IgE expression was seen in the positive control (PC; Group 2) group compared with the normal control (NC; Group 1) group in the BLG-induced food allergy mouse model. The prevention (pre; Group 3) and pre-treatment (tre; Group 4) groups following B. infantis CGMCC313-2 administration showed decreased expression. The statistical differences are represented as follows: ^aP < 0.05; ^bP < 0.01, and ^cP < 0.001.