Diagnostic value evaluation of trefoil factors family 3 for the early detection of colorectal cancer

Table 2 Diagnostic evaluation of trefoil factors family, carcino-embryonic antigen alone or combination for discriminating colorectal adenoma and colorectal cancer in the training group

Indicator	Groups	AUC (95%CI)	Cutoff value	Sensitivity	Specificity
TFF3	CA vs CRC	0.834 (0.796, 0.873)	29.89	75.23%	78.28%
	CA vs early stage CRC	0.751 (0.691, 0.812)	29.89	58.54%	78.28%
	CA vs advanced CRC	0.886 (0.849, 0.923)	34.07	75.00%	89.39%
CEA	CA vs CRC	0.683 (0.630, 0.737)	4.96	57.01%	85.86%
	CA vs early CRC	0.648 (0.563, 0.734)	4.53	56.10%	81.31%
	CA vs advanced stage CRC	0.705 (0.641, 0.770)	4.96	60.61%	85.86%
TFF3+CEA	CA vs CRC	0.883 (0.851, 0.915)	0.57	73.83%	88.38%
	CA vs early stage CRC	0.823 (0.768, 0.878)	0.41	76.83%	77.27%
	CA vs advanced stage CRC	0.919 (0.888, 0.951)	0.57	81.82%	88.38%

TFF3: Trefoil factors family; CA: Colorectal adenoma; CRC: Colorectal cancer; AUC: Area under curve.