Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22

Figure 7 Effects of interleukin-22 on expression of α-smooth muscle antigen (magnification × 400). A: Control group; B: Model group; C: 10 ng/mL IL-22 group; D: 20 ng/mL IL-22 group; E: 50 ng/mL IL-22 group. All HSC-T6 cells with α-SMA positive expression had brown granules in the cytoplasm, however, the degree of staining varied. In the control group, the cytoplasm was stained light brown, whereas it was obviously deepened in the model group. When treated with different concentrations of IL-22, the staining in the cytoplasm was gradually reduced in a dose-dependent manner. IL: Interleukin; SMA: Smooth muscle antigen.