Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22

doi:10.3748/wjg.v23.i11.2002

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2017; 23(11): 2002-2011
Published online Mar 21, 2017. doi: 10.3748/wjg.v23.i11.2002

Table 2 Effects of interleukin-22 on the acetaldehyde-induced HSC-T6 cells proliferation

Group	OD	Proliferation inhibition rate
Control group	0.3854 ± 0.0366
Model group	0.7860 ± 0.0129^a	-
10 ng/mL IL-22 group	0.6761 ± 0.0129^a^c	14%
20 ng/mL IL-22 group	0.5903 ± 0.0164^a^c	25%
50 ng/mL IL-22 group	0.5095 ± 0.0101^a^c	35%

OD was significantly decreased along with increased IL-22 dose, indicating that IL-22 dose-dependently inhibited proliferation of HSCs. Data are expressed as mean ± SD.

^aP < 0.05 vs the control group;

^cP < 0.05 vs the model group. HSCs: Hepatic stellate cells; IL: Interleukin.

Citation: Ni YH, Huo LJ, Li TT. Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22. World J Gastroenterol 2017; 23(11): 2002-2011
URL: https://www.wjgnet.com/1007-9327/full/v23/i11/2002.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i11.2002