Role of autophagy in the pathogenesis of inflammatory bowel disease

doi:10.3748/wjg.v23.i11.1944

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2017; 23(11): 1944-1953
Published online Mar 21, 2017. doi: 10.3748/wjg.v23.i11.1944

Table 1 Genetic variants related to inflammatory bowel disease and autophagy

Gene	Chromosomal site	Relation to autophagy
NOD2	16q12.1	Intracellular bacterial sensing
		Autophagosome formation
ATG16L1	2p37.1	Autophagosome formation
		Suppressing Paneth cells
IRGM	5q33.1	Phagosome maturation
		Virus-induced autophagy
IL-23R	1p31.3	Through effects on IL-1 secretion
XIAP	Xq25	Physiological inhibitor of autophagy
LRRK2	12q12	Autophagosomal-lysosomal degradation
ULK1	12q24.33	Regulated by TORC1 and AMPK
VDR	12q13.11	Regulate the expression of NOD2
MTMR3	22q12.2	Autophagosome formation

Citation: Iida T, Onodera K, Nakase H. Role of autophagy in the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2017; 23(11): 1944-1953
URL: https://www.wjgnet.com/1007-9327/full/v23/i11/1944.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i11.1944