ECRG2 enhances the anti-cancer effects of cisplatin in cisplatin-resistant esophageal cancer cells via upregulation of p53 and downregulation of PCNA

Figure 1 Survival rate of EC9706 and EC9706/cisplatin (DDP) cells treated with various concentrations of DDP. A dose-dependent association between the survival rate of EC9706 and EC9706/DDP cells and the concentration of DDP can be observed. The survival of EC9706 cells was significantly lower compared to EC9706/DDP cells following treatment with various concentrations of DDP. The IC50 of DDP in EC9706 cells is 3.34 ± 0.27 μg/mL, while the IC50 of DDP in EC9706/DDP cells is 16.83 ±1.46 μg/mL.