Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer

Figure 3 Interleukin-6 expression is significantly correlated with histological differentiation and TNM stage. A: Poorly differentiated colorectal tumours showed higher expression of IL-6 than moderately and well differentiated colorectal tumours; B: Comparison of immunohistochemical scores of IL-6 according to histological differentiation (P < 0.05); C: Strong immunoreactivity was more likely to present with advanced-stage (stage III/IV) CRC compared to early-stage (stage I/II); D: Comparison of immunohistochemical scores of IL-6 according to TNM stage (P < 0.001).