Serum HER2 as a predictive biomarker for tissue HER2 status and prognosis in patients with gastric cancer

doi:10.3748/wjg.v23.i10.1836

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2017; 23(10): 1836-1842
Published online Mar 14, 2017. doi: 10.3748/wjg.v23.i10.1836

Table 2 Diagnostic performance of serum HER2 extracellular domain for tissue HER2 status at different cut-off values

Cut-off values (ng/mL)	True positive	False positive	True negative	False negative	Sensitivity (95%CI)	Specificity (95%CI)
15.00¹	23	35	165	16	0.59 (0.42-0.74)	0.83 (0.77-0.88)
24.75²	21	15	185	18	0.54 (0.37-0.70)	0.93 (0.88-0.96)

¹Value recommended by FDA for breast cancer;

²Value determined by Youden’s index in ROC plot.

Citation: Shi HZ, Wang YN, Huang XH, Zhang KC, Xi HQ, Cui JX, Liu GX, Liang WT, Wei B, Chen L. Serum HER2 as a predictive biomarker for tissue HER2 status and prognosis in patients with gastric cancer. World J Gastroenterol 2017; 23(10): 1836-1842
URL: https://www.wjgnet.com/1007-9327/full/v23/i10/1836.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i10.1836