Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis

Table 5 Significant predictive factors for cancer-specific survival in COX proportional-hazard analysis

Prognostic factor	Univariate HR (95%CI)	P value	Multivariate HR (95%CI)	P value
Age	0.404 (0.189-0.864)	0.019	0.262 (0.106-0.647)	0.004
Gender	1.137 (0.565-2.287)	0.719	1.065 (0.450-2.519)	0.887
Histopathological type	0.526 (0.126-2.193)	0.378	0.380 (0.080-1.809)	0.224
Tumor differentiation	0.939 (0.611-1.445)	0.775	0.701 (0.395-1.246)	0.226
T	1.556 (1.030-2.350)	0.036	0.979 (0.578-1.657)	0.937
N	2.961 (1.954-4.485)	0.000	1.668 (0.716-3.889)	0.236
M	12.519 (4.593-34.120)	0.000	2.728 (0.672-11.064)	0.160
Stage	4.507 (2.706-7.507)	0.000	2.718 (1.003-7.368)	0.039
TFF1	1.805 (0.929-3.509)	0.081	1.539 (0.661-3.579)	0.317
TFF3	0.382 (0.178-0.819)	0.013	0.224 (0.085-0.593)	0.003
TWIST1	2.819 (1.441-5.515)	0.002	1.904 (0.847-4.278)	0.119