Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis

doi:10.3748/wjg.v23.i1.110

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Jan 7, 2017; 23(1): 110-120
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.110

Table 4 Correlation between TFF1, TFF3, and TWIST1 expression and clinicopathological Characteristics of colorectal cancers n (%)

Characteristicn = 75	TFF1			TFF3			TWIST1
Characteristicn = 75	Low	High	P value	Low	High	P value	Low	High	P value
Age (yr)			0.299			0.368			0.840
≤ 60	28 (63.6)	17 (54.8)		27 (57.4)	18 (64.3)		31 (60.8)	14 (58.3)
> 60	16 (36.4)	14 (45.2)		20 (42.6)	10 (35.7)		20 (39.2)	10 (41.7)
Gender			0.369			0.146			0.134
Male	30 (68.2)	18 (58.1)		33 (70.2)	15 (53.6)		30 (58.8)	18 (75.0)
Female	14 (31.8)	13 (41.9)		14 (29.8)	13 (46.4)		21 (41.2)	6 (25.0)
Histology			0.089			0.475			0.397
Adenocarcinoma	42 (95.5)	26 (83.9)		42 (89.4)	26 (92.9)		47 (92.2)	21 (87.5)
Mucinous	2 (4.5)	5 (16.1)		5 (10.6)	2 (7.1)		4 (7.8)	3 (12.5)
Differentiation			0.029			0.136			0.234
Well	10 (22.7)	12 (38.7)		15 (31.9)	7 (25.0)		18 (35.3)	4 (16.7)
Moderate	16 (36.4)	15 (48.4)		22 (46.8)	9 (32.1)		20 (39.2)	11 (45.8)
Poor	18 (40.9)	4 (12.9)		10 (21.3)	12 (42.9)		13 (25.5)	9 (37.5)
Location			0.802			0.411			0.847
Colon	31 (70.5)	21 (67.7)		31 (66.0)	21 (75)		35 (68.6)	17 (70.8)
Rectum	13 (29.5)	10 (32.3)		16 (34.0)	7 (25)		16 (31.4)	7 (30.7)
T			0.545			0.651			0.246
1	2 (4.5)	0		1 (2.1)	1 (3.6)		1 (2.0)	1 (4.2)
2	10 (22.7)	9 (29.0)		14 (29.8)	5 (17.9)		16 (31.4)	3 (12.5)
3	13 (29.5)	7 (22.6)		11 (23.4)	9 (32.1)		11 (21.6)	9 (37.5)
4	19 (43.2)	15 (48.4)		21 (44.7)	13 (46.4)		23 (45.1)	11 (45.8)
N			0.143			0.034			0.000
No	26 (59.1)	13 (41.9)		20 (42.6)	19 (67.9)		34 (66.7)	5 (20.8)
Yes	18 (40.9)	18 (58.1)		27 (57.4)	9 (32.1)		17 (33.3)	19 (79.2)
M			0.484			0.267			0.288
No	41 (93.2)	28 (90.3)		42 (89.4)	27 (96.4)		48 (94.1)	21 (87.5)
Yes	3 (6.8)	3 (9.7)		5 (10.6)	1 (3.6)		3 (5.9)	3 (12.5)
Staging			0.917			0.031			0.003
I	9 (20.5)	6 (19.4)		11 (23.4)	4 (14.3)		13 (25.5)	2 (8.3)
II	17 (38.6)	10 (32.3)		11 (23.4)	16 (57.1)		23 (45.1)	4 (16.7)
III	15 (34.1)	12 (38.7)		20 (42.6)	7 (25.0)		12 (23.5)	15 (62.5)
IV	3 (6.8)	3 (9.7)		5 (10.6)	1 (3.6)		3 (5.9)	3 (12.5)

CRC: Colorectal cancer; MNT: Matched normal tissue; MLN: Metastatic lymph node; Liver M: Liver metastasis.

Citation: Yusup A, Huji B, Fang C, Wang F, Dadihan T, Wang HJ, Upur H. Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis. World J Gastroenterol 2017; 23(1): 110-120
URL: https://www.wjgnet.com/1007-9327/full/v23/i1/110.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i1.110