New role and molecular mechanism of Gadd45a in hepatic ﬁbrosis

doi:10.3748/wjg.v22.i9.2779

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2016; 22(9): 2779-2788
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2779

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Figure 5 Gadd45a exerts reactive oxygen species scavenging effects by upregulating the expression of antioxidant enzymes. A: The effects of Gadd45a on ROS generation in CCl₄-pretreated HSCs treated with pcDNA3.1, PCDNA3.1-Gadd45a, scrambled siRNA, and Gadd45a siRNA were detected by ﬂow cytometry; B: Effects of Gadd45a on HO-1 and NQO1 RNA expression in CCl₄-pretreated HSCs treated with pcDNA3.1, PCDNA3.1-Gadd45a, scrambled siRNA, and Gadd45a siRNA; C: Effects of Gadd45a on HO-1 and NQO1 protein expression in CCl₄-pretreated HSCs treated with pcDNA3.1, PCDNA3.1-Gadd45a, scrambled siRNA, and Gadd45a siRNA. HSC: Hepatic stellate cells; ROS: Reactive oxygen species.

Citation: Hong L, Sun QF, Xu TY, Wu YH, Zhang H, Fu RQ, Cai FJ, Zhou QQ, Zhou K, Du QW, Zhang D, Xu S, Ding JG. New role and molecular mechanism of Gadd45a in hepatic ﬁbrosis. World J Gastroenterol 2016; 22(9): 2779-2788
URL: https://www.wjgnet.com/1007-9327/full/v22/i9/2779.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i9.2779