New role and molecular mechanism of Gadd45a in hepatic fibrosis

Figure 3 Gadd45a inhibits the expression of extracellular matrix proteins and α-smooth muscle actin in CCl₄-treated hepatic stellate cells. A: Expression of type I collagen, fibronectin, and α-SMA in HSCs treated with CCl₄vs saline for 24 h; B: Expression of Gadd45a, Gadd45b, and Gadd45g in HSCs treated with CCl₄vs saline for 24 h; C: Expression of type I collagen, fibronectin, α-SMA, Gadd45a, Gadd45b, and Gadd45g in HSCs transfected with pcDNA3.1-Gadd45a or siRNA-Gadd45a. HSC: Hepatic stellate cell; SMA: Smooth muscle actin.