New role and molecular mechanism of Gadd45a in hepatic fibrosis

Figure 1 Expression of fibrogenic proteins and extracellular matrix deposition in the liver of mice exposed to CCl₄. A: Relative mRNA expression of collagen I, fibronectin, and α-SMA after 1, 2, 3, and 4 wk of CCl₄ treatment, as determined by quantitative RT-PCR; B: Protein expression of collagen I, fibronectin, and α-SMA after 1, 2, and 4 wk of CCl₄ treatment, as determined by Western blot; C: Picrosirius red staining shows hepatic collagen deposition in mice treated with CCl₄ for 4 wk; saline treatment served as the control group. SMA: Smooth muscle actin.