Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma

Figure 1 Regulation of insulin-like growth factor signaling pathway by microRNAs in hepatocellular carcinoma. A schematic representation indicating the insulin-like growth factor (IGF) signaling pathway with its different members. MicroRNAs were shown to impact differentially IGF members. Some microRNAs induce the expression of their downstream IGF target (showed as an arrow), while others inhibit the expression of their downstream targets (showed as dash-ended line). Interestingly, some microRNAs showed an inhibitory effect on their downstream target directly as well as indirectly, such as miR-1275 and Let-7a.