Prognostic value of perioperative leukocyte count in resectable gastric cancer

Table 4 Univariate and multivariate Cox regression analysis for gastric cancer-related survival

Factors	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age (yr)
≥ 58 vs < 58	1.036	0.811-1.324	0.776	-	-	-
Sex
Female vs male	1.033	0.794-1.345	0.809	-	-	-
Histology
Differentiated vs undifferentiated	1.661	1.115-2.475	< 0.001	1.261	0.839-1.896	0.265
Borrmann type
IV vs I/II/III	2.634	1.726-4.018	< 0.001	1.886	1.207-2.948	0.005
Tumor status
pT3 + pT4 vs pT1 + pT2	3.186	2.123-4.782	< 0.001	1.230	0.667-2.268	0.507
Lymph node metastasis
Yes vs no	3.098	2.128-4.512	< 0.001	1.485	0.871-2.533	0.147
pTNM stage
II vs I	2.713	1.318-5.583	0.007	1.813	0.756-4.350	0.183
III vs I	6.449	3.301-12.597	< 0.001	2.723	1.941-7.882	0.015
IV vs I	10.624	4.909-22.995	< 0.001	4.849	1.610-14.610	0.005
Vascular or neural invasion
Yes vs no	1.780	1.393-2.274	< 0.001	1.324	1.023-1.713	0.033
Operation method
Total gastrectomy vs Subtotal gastrectomy	1.425	1.113-1.824	0.005	1.198	0.931-1.542	0.159
Resection margins
R1 vs R0	2.081	1.624-2.667	< 0.001	1.904	1.298-2.792	0.001
Chemotherapy regimens
Triplet or doublet vs singlet or none	2.522	1.379-4.614	0.003	2.369	1.289-4.356	0.005
Intraoperative blood loss (mL)
> 200 vs ≤ 200	1.146	0.718-1.828	0.568	-	-	-
Intraoperative blood transfusion
Yes vs No	1.237	0.835-1.831	0.289	-	-	-
Preoperative WBC count (× 109/L)
≥ 5.6 vs < 5.6	1.542	1.204-1.975	0.001	1.553	1.205-2.001	0.001
P-leukopenia
Positive vs negtive	1.479	1.100-1.988	0.010	1.660	1.226-2.247	0.001

P-leukopenia, defined as a preoperative WBC ≥ 4.0 × 10⁹/L and postoperative WBC < 4.0 × 10⁹/L, and an absolute decrease postoperatively of ≥ 0.5 × 10⁹/L. CI: Confidence interval; HR: Hazard ratio; WBC: White blood cell count.