Prognostic value of perioperative leukocyte count in resectable gastric cancer

Table 3 Relationships between white blood cell count and patients’ clinicopathologic features n (%)

Factors	Preoperative WBC count (×109/L)		P value	P-leukopenia		P value
	< 5.6	≥5.6		Positive	Negative
All patients	295 (48.0)	319 (52.0)		107 (17.4)	507 (82.6)
Age (yr)
< 58	143 (51.1)	137 (48.9)	0.194	51 (18.2)	229 (81.8)	0.670
≥ 58	152 (45.5)	182 (54.5)		56 (16.8)	278 (83.2)
Sex
Male	192 (44.7)	238 (55.3)	0.011	70 (16.3)	360 (83.7)	0.248
Female	103 (56.0)	81 (44.0)		37 (20.1)	147 (79.9)
Tumor site
Cardia	74 (50.0)	74 (50.0)	0.823	29 (19.6)	119 (80.4)	0.664
Fundus	6 (60.0)	4 (40.0)		1 (10.0)	9 (90.0)
Body	112 (46.5)	129 (53.5)		39 (16.2)	202 (83.8)
Antrum	94 (48.7)	99 (51.3)		36 (18.7)	157 (81.3)
Multi-site	9 (40.9)	13 (59.1)		2 (9.1)	20 (90.9)
Histology
Differentiated	35 (39.3)	54 (60.7)	0.085	8 (9.0)	81 (91.0)	0.023
Undifferentiated	260 (49.5)	265 (50.5)		99 (18.9)	426 (81.1)
Borrmann type
I/II/III	278 (48.1)	300 (51.9)	0.919	101 (17.5)	477 (82.5)	0.901
IV	17 (47.2)	19 (52.8)		6 (16.7)	30 (83.3)
Tumor status
pT1 + pT2	78 (59.5)	53 (40.5)	0.003	18 (13.7)	113 (86.3)	0.198
pT3 + pT4	217 (44.9)	266 (55.1)		91 (18.8)	392 (81.2)
Node status
pN0	84 (56.0)	64 (44.0)	0.011	25 (16.7)	125 (83.3)	0.901
pN1 + pN2 + pN3	209 (45.0)	255 (55.0)		82 (17.7)	382 (82.3)
pTNM stage
I + II	123 (54.7)	102 (45.3)	0.015	38 (16.9)	187 (83.1)	0.743
III + IV	172 (44.2)	21 (55.8)		71 (18.3)	318 (81.7)
Vascular or neural invasion
Negative	168 (49.9)	169 (50.1)	0.331	60 (17.8)	277 (82.2)	0.831
Positive	127 (45.8)	150 (54.2)		47 (17.0)	230 (83.0)
Gastrectomy method
Promixal	41 (51.3)	39 (48.7)	0.742	15 (18.7)	65 (81.3)	0.598
Distal	143 (48.5)	152 (51.5)		55 (18.6)	240 (81.4)
Total	111 (46.4)	128 (53.6)		37 (15.5)	202 (84.5)
Resection margins
R0	215 (49.3)	221 (50.7)	0.329	77 (17.7)	359 (82.3)	0.907
R1	80 (44.9)	98 (55.1)		30 (16.9)	148 (83.1)
Intraoperative blood loss (mL)
≤ 200	273 (48.0)	296 (52.0)	0.906	101 (15.1)	468 (84.9)	0.545
> 200	22 (48.9)	23 (51.1)		6 (21.1)	39 (78.9)
Intraoperative blood transfusion
No	251 (46.7)	286 (53.3)	0.099	98 (18.2)	439 (81.8)	0.198
Yes	44 (57.1)	33 (42.9)		9 (11.7)	68 (88.3)
Preoperative WBC count (× 109/L)
< 5.6	-	-	-	64 (21.7)	231 (78.3)	0.008
≥ 5.6	-	-		43 (13.5)	276 (86.5)

P-leukopenia, defined as a preoperative WBC ≥ 4.0 × 10⁹/L and postoperative WBC < 4.0 × 10⁹/L, and an absolute decrease postoperatively of ≥ 0.5 × 10⁹/L. WBC: White blood cell count.