Condyloma acuminatum of the anal canal, treated with endoscopic submucosal dissection

Figure 3 Histologic and immunohistochemical analyses of a specimen from the anal canal. A: A low-power scan of the glass slide showing papillomatosis, parakeratosis, dyskeratosis, acanthosis, and distinct koilocytosis; B: A low-power scan shows an underlying chronic inflammatory cell infiltrate and basal cell atypical hyperplasia; C: Condylomata acuminatum with accentuated transepithelial lymphocytic infiltrate was diagnosed as anal intraepithelial neoplasia 2; D: Immunohistochemical peroxidase staining for p53 protein showing negative cells; E: Ki-67 stain showing 40% positive cells through the layer of the epithelium; F: Immunohistochemical studies indicate positive staining for papillomavirus common antigen.