Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease

doi:10.3748/wjg.v22.i8.2592

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Feb 28, 2016; 22(8): 2592-2600
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2592

Table 1 Clinico-demographic characteristics of the study population n (%)

	H. pylori (+)n = 1636	H. pylori (-)n = 2027	P value
Age (yr)	54 (46-61)	53.0 (43-60)	< 0.001
Male	988 (60.4)	1153 (56.9)	0.032
Body mass index (kg/m²)	23.8 (21.8-25.7)	23.5 (21.4-25.5)	0.002
Diabetes	215 (13.1)	225 (11.1)	0.059
Hypertension	453 (27.7)	483 (23.8)	0.008
Metabolic syndrome	334 (20.4)	385 (19.0)	0.281
Smoking	699 (42.7)	894 (44.1)	0.403
Alcohol	893 (54.6)	1135 (56.0)	0.394
Fasting glucose (mg/dL)	93 (86-103)	93 (86-102)	0.611
Insulin (mIU/mL)	5.9 (3.9-8.7)	5.8 (3.9-8.5)	0.732
HOMA-IR¹	1.4 (0.9-2.2)	1.3 (0.9-2.1)	0.582
Hemoglobin A_1c (%)	5.5 (5.2-5.7)	5.5 (5.2-5.8)	0.763
Total cholesterol (mg/dL)	201 (180-225)	195 (173-220)	< 0.001
Triglyceride (mg/dL)	89 (58-137)	86 (57-131)	0.202
HDL-C (mg/dL)	50 (43-59)	51 (43-60)	0.020
LDL-C (mg/dL)	126 (104.0-147.8)	120 (98-141)	< 0.001
AST (IU/L)	24 (20-30)	24 (20-29)	0.596
ALT (IU/L)	24 (18-34)	24 (18-34)	0.249
AST/ALT	1.0 (0.8-1.2)	1.0 (0.8-1.2)	0.198
GGT (IU/L)	27 (18-43)	25 (17-43)	0.043
C-reactive protein (mg/dL)	0.06 (0.03-0.13)	0.06 (0.03-0.13)	0.905
HSI²	33.2 (30.3-36.2)	32.6 (29.8-36.0)	0.005
HSI > 36	505 (30.9)	440 (21.7)	0.173
NAFLD-LFS³	-1.7 (-2.4 - -0.7)	-1.8 (-2.4 - -0.7)	0.122
NAFLD > -0.640	469 (28.7)	385 (19.0)	0.778

¹HOMA-IR = (fasting glucose × fasting insulin)/405;

²HSI = 8 × ALT/AST + body mass index (if diabetes mellitus, +2; if female, +2); ³NAFLD-LFS = -2.89 + 1.18 × metabolic syndrome (yes = 1, no = 0) + 0.45 × type 2 diabetes (yes = 2, no = 0) + 0.15 × insulin (mU/L) + 0.04 × AST (U/L) - 0.94 × AST/ALT. HOMA-IR: Homeostatic model assessment of insulin resistance; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyltransferase; HSI: Hepatic steatosis index; NAFLD: Nonalcoholic fatty liver disease; NAFLD-LFS: Nonalcoholic fatty liver disease liver fat score.

Citation: Baeg MK, Yoon SK, Ko SH, Noh YS, Lee IS, Choi MG. Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease. World J Gastroenterol 2016; 22(8): 2592-2600
URL: https://www.wjgnet.com/1007-9327/full/v22/i8/2592.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i8.2592