Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer

Table 2 Multivariate analysis of the relationship between n-3 polyunsaturated fatty acid and cytokines

	C18:3 n-3 (quartiles),%1					C20:5 n-3 (quartiles),%1						C22:5 n-3 (quartiles),%1
Quartiles limits	< 0.33	0.33-0.47	0.47-0.61	> 0.61	P value for trend	< 0.20	0.20-0.31	0.31-0.46	> 0.46	P value for trend	Quartiles limits	< 0.32	0.32-0.40	0.40-0.49	> 0.49	P value for trend
Median	0.26	0.41	0.53	0.74		0.15	0.25	0.37	0.60		Median	0.27	0.36	0.44	0.59
IL-10 (pg/mL)	2.58	2.34	1.93	2.42	0.465	2.38	1.96	2.54	2.46	0.959	IL-10	2.47	2.66	2.06	2.00	0.478
IL-6 (pg/mL)	1.75	1.43	1.34	1.90	0.184	1.45	1.89	1.74	2.09	0.810	IL-6	1.55	1.71	1.79	1.94	0.088
TNF-α (pg/mL)	7.35	7.78	8.36	7.43	0.644	7.45	8.59	7.43	6.92	0.821	TNF-α	7.27	8.71	6.73	7.43	0.373
MMP-7 (ng/mL)	3.02	2.97	2.87	3.27	0.520	2.62	3.10	3.10	3.14	0.412	MMP-7	2.66	3.08	3.00	3.14	0.323
	C22:6 n-3 (quartiles),%1					PUFA n-31
Quartiles limits	< 1.56	1.56-2.13	2.13-2.62	> 2.62	P value for trend	< 2.79	2.79-3.30	3.30-4.08	> 4.08	P value for trend
Median	1.31	1.79	2.36	3.01		2.45	3.04	3.73	4.45
IL-10 (pg/mL)	2.63	2.64	1.93	2.30	0.838	2.63	2.25	1.98	2.34	0.074
IL-6 (pg/mL)	1.79	1.87	1.43	1.34	0.679	1.85	1.51	1.25	1.83	0.279
TNF-α (pg/mL)	7.03	7.66	7.07	8.40	0.636	7.27	7.08	9.49	7.21	0.728
MMP-7 (ng/mL)	2.94	3.13	3.26	2.97	0.827	2.92	2.69	3.61	3.20	0.160

¹The association of n-6 PUFA and cytokines were adjusted for potential confounding factors, including age, sex, smoke, alcohol drinking, body mass index, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, total energy, protein, fat and carbohydrate intake. PUFA: Polyunsaturated fatty acids; IFN-γ: Interferon gamma; IL-10: Interleukin-10; TNF-α: Tumor necrosis factor-α; MMP-7: Matrix metalloproteinase-7.