Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer

Table 1 Multivariate analysis of the relationship between n-6 polyunsaturated fatty acid and cytokines

	C18:2 n-6 (quartiles),%1					C18:3 n-6 (quartiles),%1					C20:3 n-6 (quartiles),%1
Quartiles limits	< 22.74	22.74-24.46	24.46-26.50	> 26.50	P value for trend	< 0.21	0.21-0.28	0.28-0.34	> 0.34	P value for trend	< 1.28	1.28-1.59	1.59-1.92	> 1.92	P value for trend
Median	21.55	23.75	25.47	28.54		0.17	0.24	0.31	0.40		1.05	1.38	1.72	2.13
IFN-γ (pg/mL)	0.55	0.22	0.81	0.33	0.834	0.41	0.27	0.40	0.46	0.943	0.30	0.46	0.34	0.41	0.760
IL-10 (pg/mL)	2.63	2.06	2.70	1.98	0.959	2.19	2.27	1.99	2.68	0.828	2.04	2.10	2.50	2.63	0.552
IL-8 (pg/mL)	66.00	48.43	51.01	30.76	0.259	57.55	21.77	45.19	73.44	0.436	62.18	34.07	47.60	64.69	0.266
TNF-α (pg/mL)	7.36	7.34	9.23	6.68	0.443	9.74	6.69	7.32	8.30	0.450	7.76	6.97	8.29	8.43	0.743
MMP-2 (ng/mL)	12.26	12.86	10.89	8.80	0.485	13.54	9.68	7.54	12.24	0.488	10.79	11.57	12.86	11.62	0.863
MMP-7 (ng/mL)	2.96	3.10	2.94	3.06	0.735	3.39	2.55	3.22	3.00	0.426	3.01	3.10	2.62	3.14	0.444
MMP-9 (ng/mL)	12.03	12.16	10.75	10.71	0.058	10.86	9.89	12.14	12.57	0.255	10.61	9.81	14.03	11.83	0.187
	C20:4 n-6 (quartiles),%1					C22:5 n-6 (quartiles),%1					PUFA n-6 (quartiles),%1
Quartiles limits	< 6.72	6.72-7.75	7.75-9.01	> 9.01	P value for trend	< 0.13	0.13-0.18	0.18-0.25	> 0.25	P value for trend	< 32.52	32.52-34.53	34.53-36.58	36.58	P value for trend
edian	5.99	7.29	8.19	9.74		0.06	0.15	0.21	0.31		31.07	33.65	35.56	37.92
IFN-γ (pg/mL)	0.41	0.46	0.22	0.41	0.298	0.52	0.22	0.27	0.41	0.709	0.30	0.67	0.41	0.27	0.610
IL-10 (pg/mL)	2.14	2.97	1.85	2.63	0.681	2.20	1.74	2.68	2.57	0.453	2.23	2.77	2.00	2.01	0.287
IL-8 (pg/mL)	41.89	44.92	41.14	65.83	0.129	46.68	30.06	66.74	62.79	0.348	47.90	41.00	78.72	43.19	0.983
TNF-α (pg/mL)	6.45	7.78	7.39	9.38	0.182	7.32	6.67	8.41	7.43	0.457	7.17	6.83	9.38	8.61	0.480
MMP-2 (ng/mL)	12.39	11.16	8.45	13.54	0.741	9.75	6.28	14.83	13.41	0.223	10.60	12.19	13.41	8.88	0.065
MMP-7 (ng/mL)	3.02	3.04	2.94	3.52	0.055	3.10	2.80	2.87	3.55	0.981	3.04	2.91	3.20	3.03	0.870
MMP-9 (ng/mL)	10.94	10.93	11.96	11.81	0.200	10.91	9.97	13.00	11.01	0.493	10.32	12.40	12.56	10.89	0.868

¹The association of n-6 PUFA and cytokines were adjusted for potential confounding factors, including age, sex, smoke, alcohol drinking, body mass index, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, total energy, protein, fat and carbohydrate intake. PUFA: Polyunsaturated fatty acids; IFN-γ: Interferon gamma; IL-10: Interleukin-10; TNF-α: Tumor necrosis factor-α; MMP-2: Matrix metalloproteinase-2.