Copyright
©The Author(s) 2016.
World J Gastroenterol. Feb 28, 2016; 22(8): 2475-2482
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2475
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2475
Estrogen receptors | Isoform | Association with gastric cancer |
ERα | ERα66 | No significant correlation between ERα66 and gastric cancer is found[27] |
No positive significant difference in both male and female[27,28] | ||
Incidence higher in poorly differentiated adenocarcinoma[28] | ||
Association with diffused type gastric cancer is found[31] | ||
Associated with poor overall survival[31] | ||
ERα46 | No reported result has been up to date | |
ERα36 | Expressed highly in gastric cancer[34] | |
Expression correlated with lymph node metastasis[34] | ||
Expressed in plasma membrane and cytoplasm of gastric cancer[34] | ||
ERβ | ERβ1 | Associated with low tumor grades[32] |
ERβ2 | Presence could have protective effect against invasion[32] | |
ERβ3 | Absence of ERβ a significant independent prognostic factor for poor OS[15] | |
ERβ4 | ERβ5 is associated with PTNM stage[39] | |
ERβ5 |
- Citation: Rahman MSU, Cao J. Estrogen receptors in gastric cancer: Advances and perspectives. World J Gastroenterol 2016; 22(8): 2475-2482
- URL: https://www.wjgnet.com/1007-9327/full/v22/i8/2475.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i8.2475