Review
Copyright ©The Author(s) 2016.
World J Gastroenterol. Feb 28, 2016; 22(8): 2475-2482
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2475
Table 1 Summary of the association between estrogen receptor isoforms and gastric cancer
Estrogen receptorsIsoformAssociation with gastric cancer
ERαERα66No significant correlation between ERα66 and gastric cancer is found[27]
No positive significant difference in both male and female[27,28]
Incidence higher in poorly differentiated adenocarcinoma[28]
Association with diffused type gastric cancer is found[31]
Associated with poor overall survival[31]
ERα46No reported result has been up to date
ERα36Expressed highly in gastric cancer[34]
Expression correlated with lymph node metastasis[34]
Expressed in plasma membrane and cytoplasm of gastric cancer[34]
ERβERβ1Associated with low tumor grades[32]
ERβ2Presence could have protective effect against invasion[32]
ERβ3Absence of ERβ a significant independent prognostic factor for poor OS[15]
ERβ4ERβ5 is associated with PTNM stage[39]
ERβ5