Molecular alterations in gastric cancer with special reference to the early-onset subtype

Table 2 Early-onset gastric cancer features

Factors	Early-onset gastric cancer	Ref.
SNP	rs10052016 at 5p15	[198]
CIN	Gain of copy number at 17q, 19q, and 20q	[10]
	No loss of RUNX3
	Infrequent loss of TFF1 expression
	More frequent expression of low-molecular-weight isoforms of cyclin E
LOH	Infrequent LOH	[10]
MSI	Lack of MSI	[10]
	vs 30% incidence	[124]
Others	Low COX-2 expression	[10]
	Male predominance	[195]
	Tendency to metastases	[196]

SNP: Single-nucleotide polymorphism; CIN: Chromosomal instability; LOH: Loss of heterozygosity; MSI: Microsatellite instability.