Interleukin-22 contributes to liver regeneration in mice with concanavalin A-induced hepatitis after hepatectomy

Figure 2 Serum alanine aminotransferase and aspartate aminotransferase levels after partial hepatectomy. A-D: Decreases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were observed after 32 h, particularly from 40 h to 1 wk. Compared to the concanavalin A (ConA) + PHX group, the serum ALT and AST levels of the ConA + PHX + interleukin (IL)-22 group decreased, and the difference were significant at all time points (^cP < 0.01). Furthermore, with the recombinant IL-22 pretreatment, the ALT and AST levels in the ConA + PHX + IL-22 group decreased to significantly greater extents than the levels in the ConA and PHX groups at 40 h, 48 h and 1 wk (^aP < 0.05).