Interleukin-22 contributes to liver regeneration in mice with concanavalin A-induced hepatitis after hepatectomy

Figure 1 Liver weight/body weight ratios following partial hepatectomy. A and B: Increases in the liver weight/body weight ratio were observed in the PHX, concanavalin A (ConA) + PHX and ConA + PHX + interleukin (IL)-22 groups, and all groups returned to normal liver weights by 2 wk. Compared with the ConA + PHX group, the ConA + PHX + IL-22 group exhibited greater increases that reached significance at 40 h, 48 h, 1 wk and 2 wk (^aP < 0.05); these differences were particularly notable at 48 h and 1 wk (^cP < 0.01). The increases in the PHX group were significantly different from those in the ConA + PHX group at 48 h and 1 wk (^aP < 0.05); however, the increase in the PHX group at 32 h was less than that in the ConA + PHX group (^cP < 0.01). These data were correlated with the cellular swelling in the liver at 32 h in the ConA + PHX group.