Minimizing tacrolimus decreases the risk of new-onset diabetes mellitus after liver transplantation

Table 2 Clinical complications associated with mean tacrolimus trough concentration n (%)

Complications post-LT	Low-cTAC group (n = 356)	High-cTAC group (n = 172)	P value
Overweight/obesity (BMI ≥ 25)	76 (21.3)	52 (30.2)	0.026
Hypertension	48 (13.5)	19 (11.0)	0.431
Dyslipidaemia	98 (27.5)	77 (44.8)	< 0.001
Cardio-cerebral events	12 (3.4)	6 (3.5)	0.944
CKD	52 (14.6)	39 (22.7)	0.021
AR	34 (9.6)	24 (14.0)	0.129
CR	10 (2.8)	10 (5.8)	0.090
Infection	88 (24.7)	57 (33.1)	0.042
New-onset malignance	8 (2.2)	1 (0.6)	0.304

cTAC: Tacrolimus trough concentration; BMI: Body mass index; LT: Liver transplantation; CKD: Chronic kidney disease; AR: Acute rejection; CR: Chronic rejection.