Prospective evaluation of the cause of acute pancreatitis, with special attention to medicines

Table 3 Cause of acute pancreatitis in the prospective and retrospective group n (%)

	Prospective group (n = 57)		Retrospective group (n = 613)		P value
	Patients	Patients using medicines1	Patients	Patients using medicines1
Bile stone	23 (40.4)	13 (57)	271 (44.2)	4 (0.1)	< 0.001
Bile stone or alcohol	4 (7.0)	4 (100)	14 (2.3)
Alcohol	6 (10.5)	1 (17)	87 (14.2)	1 (0.1)
Hypertriglyceridemia	3 (5.2)	3 (100)	8 (1.3)
ERCP	1 (1.8)	0	19 (3.1)
PTC	1 (1.8)	0	0
Tumor/cancer pancreas	1 (1.8)	0	9 (1.5)
Pancreas divisum	2 (3.5)	1 (50)	1 (0.2)
Stone in pancreatic duct	1 (1.8)	0	1 (0.2)
Postoperative pancreatitis	0	0	3 (0.5)
Trauma	0	0	1 (0.2)
Viral infection	0	0	2 (0.3)
Medicines1	11 (19.3)	11 (100)	15 (2.4)	15 (100)
Unknown2	4 (7.0)	0	182 (29.7)	0
All	57 (100)	33 (58)	613 (100)

¹Medicines associated with pancreatitis as a side effect;

²Two of these had a previous cholecystectomy due to bile stones, suggesting small bile-stones as a possible cause. ERCP: Endoscopic retrograde cholangiopancreaticography.