Coagulopathy and transfusion therapy in pediatric liver transplantation

Table 5 Reference parameters for rotational thromboelastogram in healthy and pathologic pediatric populations

Ref.	Type of patient	Age	n	CT, s	CFT, s	MCF, mm	CLI60, %	Note
Strauss et al[28]	Pre-term	Newborn	47	185 (108-357)	80 (52-183)	57 (42-66)		Median (MIN-MAX)
	Full term		184	194 (98-588)	76 (34-208)	60 (39-71)
Oswald et al[111]	Healthy	0-3 mo	51	184 (105-285)	44 (27-88)	66 (54-73)		InTEM median (2.5%-97.5%)
		4-12 mo	55	172 (76-239)	60 (37-100)	63 (52-73)
		13-24 mo	54	161 (99-207)	61 (42-112)	64 (50-72)
		2-5 yr	70	170 (99-239)	60 (40-94)	63 (53-73)
		6-10 yr	79	168 (97-212)	64 (48-93)	62 (53-69)
		11-16 yr	50	171 (128-206)	68 (45-106)	62 (54-71)
		0-3 mo	51	48 (38-65)	57 (30-105)	62 (54-74)	87 (71-94)	ExTEM median (2.5%-97.5%)
		4-12 mo	55	53 (37-77)	72 (44-146)	60 (46-71)	86 (71-95)
		13-24 mo	54	55 (37-73)	75 (46-139)	60 (46-72)	88 (77-94)
		2-5 yr	70	56 (46-97)	72 (41-109)	61 (52-70)	86 (74-93)
		6-10 yr	79	57 (43-74)	77 (49-114)	60 (53-68)	87 (70-97)
		11-16 yr	50	59 (44-91)	81 (53-115)	62 (53-72)	88 (76-94)
Oasthaus et al[116]	Normal	211 ± 116 d	17	177 ± 28	60 ± 21	64 ± 6		InTEM (mean ± SD)
	Acyanotic	134 ± 61 d	17	178 ± 41	70 ± 16	61 ± 4
	Cyanotic	135 ± 132 d	17	194 ± 43	105 ± 68	56 ± 6
	Normal	211 ± 116 d	17	51 ± 6	71 ± 25	62 ± 6	94 ± 2	ExTEM (mean ± SD)
	Acyanotic	134 ± 61 d	17	50 ± 5	88 ± 22	59 ± 6	93 ± 2
	Cyanotic	135 ± 132 d	17	68 ± 40	141 ± 99	54 ± 9	91 ± 4
Haizinger et al[117]	ASA I	0-1 mo	6	179 ± 17	56 ± 23	68 ± 7	91 ± 2	InTEM (mean ± SD)
	ASAIII-IV cardiac		17	332 ± 207	127 ± 184	62 ± 10	93 ± 3
	ASA I	1-3 mo	6	166 ± 25	45 ± 9	69 ± 3	89 ± 2
	ASAIII-IV cardiac		6	257 ± 95	78 ± 47	61 ± 6	91 ± 2
	ASA I	3-6 mo	6	183 ± 22	49 ± 22	67 ± 7	90 ± 3
	ASAIII-IV cardiac		6	187 ± 29	53 ± 11	69 ± 4	94 ± 3
	ASA I	6-12 mo	6	172 ± 11	60 ± 17	63 ± 8	89 ± 2
	ASAIII-IV cardiac		6	196 ± 55	61 ± 11	66 ± 3	92 ± 4
	ASA I	0-1 mo	6	35 ± 12	65 ± 31	65 ± 9	91 ± 2	ExTEM (mean ± SD)
	ASAIII-IV cardiac		17	55 ± 62	119 ± 119	54 ± 10	92 ± 4
	ASA I	1-3 mo	6	35 ± 9	65 ± 12	64 ± 2	90 ± 4
	ASAIII-IV cardiac		6	35 ± 7	98 ± 43	54 ± 7	91 ± 2
	ASA I	3-6 mo	6	33 ± 9	75 ± 33	65 ± 9	89 ± 3
	ASAIII-IV cardiac		6	34 ± 15	79 ± 29	63 ± 5	94 ± 4
	ASA I	6-12 mo	6	45 ± 19	96 ± 39	59 ± 9	89 ± 2
	ASAIII-IV cardiac		6	36 ± 11	85 ± 17	58 ± 5	92 ± 3

CT: Clotting time, “r” time in TEG; CFT: Clot formation time, “k” time in TEG; MCF: Maximum clot firmness, MA in TEG; CLI60: Final clot lysis index at 60 min = LY A60 in TEG; INTEM and EXTEM are two different activated baseline analyses. ROTEM: Rotational thromboelastogram; TEG: Thromboelastogram.