Italian survey on non-steroidal anti-inflammatory drugs and gastrointestinal bleeding in children

Table 4 Detailed endoscopic findings in 51 patients presenting with gastrointestinal bleeding after non-steroidal anti-inflammatory drug use n (%)

Variables	≤3 yr(n = 11)	> 3 ≤7 yr(n = 14)	> 7 ≤16 yr(n = 26)	P value
Upper GI lesions				0.04
Proximal (esophagus and stomach)	10 (100)	12 (85.7)	15 (62.5)
Distal (duodenum)	0	2 (14.3)	9 (37.5)
Location				0.06
Esophagus	2 (18.1)	2 (14.3)	4 (15.4)
Stomach	8 (72.7)	10 (71.4)	11 (42.3)
Duodenum	0	2 (14.3)	9 (34.6)
Colon	1 (9)	0	1 (3.8)
Esophagus				0.90
Upper	0	0	0
Middle	0	0	0
Lower	2 (18.1)	2 (14.3)	4 (15.3)
Los Angeles classification				0.50
Grade A	2 (100)	2 (100)	3 (75)
Grade B	0	0	1 (25)
Grade C	0	0	0
Grade D	0	0	0
Stomach				0.09
Antrum	0	0	4 (36.4)
Body	4 (50)	4 (40)	3 (27.3)
Fundus	4 (50)	6 (60)	4 (36.4)
Type of lesions				0.40
Erythema	5 (62.5)	8 (80)	4 (36.4)
Edema	0	1 (10)	1 (9.1)
Erosions	2 (25)	1 (10)	3 (27.3)
Ulcerations	1 (12.5)	0	3 (27.3)
Duodenum				1.00
Bulb	0	2 (100)	8 (88.9)
Duodenum	0	0	1 (11.1)
Type of lesions				0.02
Nodularity	0	1 (50)	1 (11.1)
Erythema	0	1 (50)	0
Erosions	0	0	0
Ulcerations	0	0	8 (88.8)
Forrest Classification for ulcerations				0.30
Grade 1a	0	0	2 (18.2)
Grade 1b	0	0	1 (9.1)
Grade 2a	1 (100)	0	2 (18.2)
Grade 2b	0	0	0
Grade 2c	0	0	2 (15.4)
Grade 3	0	0	6 (54.5)
Colon
Transverse	1 (9)	0	0
Sigmoid	0	0	1 (3.8)
Type of lesions
Erythema	1 (100)	0	0
Edema	0	0	1 (100)

GI: Gastrointestinal; NSAIDs: Non-steroidal anti-inflammatory drugs.