Copyright
©The Author(s) 2016.
World J Gastroenterol. Feb 7, 2016; 22(5): 1736-1744
Published online Feb 7, 2016. doi: 10.3748/wjg.v22.i5.1736
Published online Feb 7, 2016. doi: 10.3748/wjg.v22.i5.1736
Table 1 Clinicopathologic and molecular differences between young-onset and late-onset colorectal cancer
Clinical and molecular characteristics | Young-onset CRC( ≤50 yr) | Late-onset CRC(> 50 yr) |
Proximal colon | X | |
Distal colon and rectum | X | |
Synchronous and metachronous CRC | X | |
Later stage at diagnosis (stage III/IV) | X | |
Mucinous/signet ring and poorly differentiated features | X | |
Typically MSS | X | |
MSI due to MLH1 gene promoter methylation | X | |
CIN | X | |
CIMP-low | X | |
CIMP-high | X | |
Microsatellite and chromosome stable CRC | X | |
Hypomethylation of LINE 1 | X |
- Citation: Ballester V, Rashtak S, Boardman L. Clinical and molecular features of young-onset colorectal cancer. World J Gastroenterol 2016; 22(5): 1736-1744
- URL: https://www.wjgnet.com/1007-9327/full/v22/i5/1736.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i5.1736