Regulating effect of TongXie-YaoFang on colonic epithelial secretion via Cl- and HCO3- channel

Figure 4 Effects of Na⁺, Cl^– and HCO₃^– on 5-HT-induced the changes of short-circuit current in rats. A: 5-HT-induced ∆Isc was higher in TXYF-formula group than in NMS + RS group when Na⁺ in apical side of colonic mucosa was taken out; B: When Na⁺ in basolateral side was taken out, ∆Isc was similar in three groups; C: 5-HT-induced ∆Isc was similar in three groups when Cl^– and HCO₃^– was respectively or entirely removed from basolateral side of colonic mucosa. ^aP < 0.05 vs NMS + RS group; ^bP < 0.01 vs NMS + RS group. ∆Isc: the changes short-circuit current; TXYF: TongXie-YaoFang; NMS: Neonatal maternal separation; RS: Restraint stress; NH: No handlings as control.