Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features

Table 3 Histopathological characteristics of previously reported cases

Author (year)	Number of patients	Background mucosa	Depth (M:SM) (µm, average)	Lymphatic invasion (+:-)	Venous invasion (+:-)	MUC2 (+:-)	MUC5AC (+:-)	MUC6 (+:-)	CD10 (+:-)	Overexpression of p53 (+:-)	Ki-67 LI (%, average)
Tsukamoto et al[4] (2007)	1	ND	M	(-)	(-)	ND	ND	(+)	ND	ND	7.9
Ueyama et al[5] (2010)	10	Normal: 7	1:9	0:10	0:10	0:10	1:9	10:0	0:10	0:10	3.6
		Metaplasia: 1	844 (150 to 4000)
		ND: 2
Fukatsu et al[6] (2011)	1	ND	SM, 100	(-)	(-)	ND	(-)	(+)	ND	ND	ND
Park et al[8] (2012)	3	Metaplasia: 2	1:2	0:3	0:3	0:3	3:0	3:0	0:3	ND	ND
		Gastritis: 1
Singhi et al[9] (2012)	10	Normal: 7	10:0	0:10	0:10	0:3	0:10	10:0	ND	0:9	2.6
		Gastritis: 3								ND: 1	(0.2-10)
Chen et al[10] (2012)	1	Normal	SM (Details unknown)	(-)	(-)	(-)	(-)	(-)	(-)	(-)	3.8
Abe et al[11] (2013)	1	Normal	SM (Details unknown)	(-)	(-)	(-)	(-)	(-)	(-)	(-)	1.9
Ueyama et al[12] (2014)	10	Normal: 9	5:5	1:9	0:10	0:10	4:6	10:0	2:8	0:10	8.6 (1-20)
		Gastritis: 1	360 (100 to 1200)
Miyazawa et al[13] (2015)	5	Normal: 4	0:5	1:4	0:5	0:5	0:5	5:0	ND	0:5	Very low: 5 (Details unknown)
		Gastritis: 1	620 (80 to 1230)
Parikh et al[14] (2015)	1	ND	SM (Details unknown)	(-)	(-)	ND	ND	ND	ND	ND	ND
Kato et al[15] (2015)	1	Normal	SM, 300	(-)	(-)	ND	ND	(+)	ND	ND	ND
Fujii et al[16] (2015)	1	Normal	SM, 300	(-)	(-)	ND	(-)	(+)	ND	ND	ND

LI: Labeling index; M: Mucosal; SM: Submucosal; ND: Not described.