Copyright
©The Author(s) 2016.
World J Gastroenterol. Dec 21, 2016; 22(47): 10465-10470
Published online Dec 21, 2016. doi: 10.3748/wjg.v22.i47.10465
Published online Dec 21, 2016. doi: 10.3748/wjg.v22.i47.10465
Table 3 Cases of γδ-hepatosplenic T-cell lymphoma in patients with Crohn’s disease on thiopurine monotherapy
Index | Age, sex | Years of thiopurine | Presentation | Treatment | Survival (mo) |
treatment (type) | |||||
Index case | 47, M | 14 (AZT) | HSM, icterus, anemia, thrombocytopenia | Ch. (CHOP) | < 1 |
Selvaraj et al[7] 2013 (AERS 6751796) | 18, M | < 1 (AZT, 6MP) | NS | NS | 7 |
Selvaraj et al[7] 2013 (AERS 7554658) | 13, M | NS (6MP) | NS | NS | NS |
Fowler et al[18] 2010 | 19, M | 6 (AZT) | SM, leucocytopenia | Ch. (NS) + splenectomy | 4 |
Fowler et al[18] 2010 | 22, M | 8 (6MP) | SM, night sweats, fever, abdominal tenderness | Ch. (NS) | Survival |
Ochenrider et al[8] 2010 | 18, M | 5 (6MP) | Fever, night sweats, SM, anemia, thrombocytopenia | Ch. (Pentostatin, ICE) + auto-SCT | 7 |
Humphreys et al[19] 2008 | 27, F | 5 (AZT) | Fever, nights sweats, pancytopenia, HSM | Interferon-α | > 31 |
Zeidan et al[20] 2007 | 31, M | 6 (6MP)1 | Chills, SM, fever, pancytopenia | Ch. (CHOP, cytarabine, ESHAP) | 7 |
Falchook et al[15] 2006 | NS | NS (6MP) | SM | Ch. (NS) | NS |
Mittal et al[21] 2006 | 18, M | 6 (AZT) | Fever, pancytopenia, HSM | Ch. (IVE, ESHAP, alemtuzumab | NS |
fludarabine) + allo-SCT | |||||
Navarro et al[22] 2003 | 35, M | 5.6 (AZT) | Fever, night sweats, HSM, anemia, thrombocytopenia | Ch. (NS) + splenectomy | NS |
Lémann et al[23] 1998 | NS | 4 (AZT) | NS | NS | NS |
- Citation: van de Meeberg MM, Derikx LAAP, Sinnige HAM, Nooijen P, Schipper DL, Nissen LHC. Hepatosplenic T-cell lymphoma in a 47-year-old Crohn’s disease patient on thiopurine monotherapy. World J Gastroenterol 2016; 22(47): 10465-10470
- URL: https://www.wjgnet.com/1007-9327/full/v22/i47/10465.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i47.10465