Clinical features of acute hepatitis E super-infections on chronic hepatitis B

Table 2 Clinical features and laboratory data for hepatitis B virus-hepatitis E virus co-infected patients with underlying decompensated or compensated liver cirrhosis n (%)

Characteristic	Decompensated	Compensated	P value
	(n = 9)	(n = 85)
Baseline characteristics
Age, yr (Q1-Q3)	58 (54.0-62.5)	55 (41.5-62.5)	0.183
Male sex	8 (88.9)	66 (77.7)	0.679
Alcohol	2 (22.2)	35 (41.2)	0.475
Smoker	3 (33.3)	27 (31.8)	0.982
Clinical features
Bilirubin > 10-fold ULN	2 (22.2)	32 (37.7)	0.480
Ascites	8 (88.9)	54 (63.5)	0.160
Infection	6 (66.7)	41 (48.2)	0.486
HE	6 (66.7)	18 (21.2)	< 0.010
GH	1 (11.1)	10 (11.8)	0.982
Outcomes of disease
Severe disease	9 (100)	64 (75.3)	0.200
Mortality	2 (22.2)	18 (21.2)	0.973
Laboratory parameters
ALT ( IU/L)	51 (37.0-114.5)	122 (41.5-545.0)	0.094
AST (IU/L)	81 (49.0-188.5)	118 (53.0-399.5)	0.253
Tbil (μmol/L)	39.5 (22.5-165.8)	85.7 (22.4-322.4)	0.433
ALB (g/dL)	28.7 (26.6-34.9)	33.2 (29.1-37.3)	0.114
INR	1.5 (1.2-1.6)	1.4 (1.2-1.8)	0.995
LEU count (109/L)	3.9 (2.0-7.5)	4.6 (3.5-6.3)	0.516
Platelet count (109/L)	54 (44.0-84.5)	85 (58.8-117.3)	0.080
NEU count (109/L)	2.8 (1.2-6.4)	3.0 (1.8-4.4)	0.933

Data are presented as median (Q1-Q3) and number of patients (%). Severe disease was defined as liver failure and/or liver decompensation. ALB: Albumin; ALT: Alanine aminotransferase; AST; Aspartate aminotransferase; GH: Gastrointestinal hemorrhage; HE: Hepatic encephalopathy; INR: International normalized ratio; LEU: Leukocytes; NEU: Neutrophil; Tbil: Total bilirubin; ULN: Upper limit of normal.