Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma

Table 3 Significant DNA methylation changes of age-related CpG sites in adenoma samples compared to normal tissue

cgID	Gene symbol	P value	Δβ (AD - N)
cg10345936	SLC36A2	3.49 × 10-10	-0.34
cg00091693	KRT20	2.49 × 10-12	-0.30
cg00075967	STRA6	2.58 × 10-9	-0.26
cg11314684	AKT3	1.03 × 10-9	-0.26
cg06462291	NT5DC3	7.45 × 10-5	-0.25
cg17099569	GLI2	1.25 × 10-10	-0.23
cg00168942	GJD4	2.48 × 10-7	-0.20
cg20828084	CEMIP	1.33 × 10-9	-0.19
cg17274064	ERG	1.82 × 10-10	-0.19
cg07408456	PGLYRP2	2.41 × 10-12	-0.19
cg03019000	TEX264	2.25 × 10-7	-0.19
cg17589341	SLC14A1	1.42 × 10-9	-0.19
cg02580606	KRT33B	9.08 × 10-5	-0.17
cg00436603	CYP2E1	1.37 × 10-8	-0.16
cg19346193	UROS	6.59 × 10-7	-0.15
cg03103192	SPATA18	1.39 × 10-7	-0.15
cg25564800	KPNA1	2.18 × 10-8	-0.14
cg06144905	PIPOX	3.63 × 10-7	-0.14
cg06952310	NCAN	2.72 × 10-4	-0.14
cg13038560	C2orf47	2.13 × 10-5	-0.13
cg22190114	NLRP8	1.67 × 10-4	-0.13
cg13302154	MGP	7.27 × 10-6	-0.13
cg01262913	DSCR9	2.67 × 10-6	-0.13
cg14258236	OR5V1	3.71 × 10-4	-0.12
cg13828047	MPI	1.01 × 10-3	-0.12
cg01459453	SELP	1.65 × 10-4	-0.12
cg14894144	LAMA3	2.29 × 10-4	-0.12
cg07337598	ANXA9	2.02 × 10-5	-0.12
cg03270204	DDR1	7.47 × 10-5	-0.12
cg12946225	HMG20B	1.37 × 10-6	-0.11
cg09646392	TNFSF13B	2.66 × 10-5	-0.10
cg19305227	SLC28A2	0.033	-0.10
cg03578041	LARP6	2.22 × 10-5	-0.10
cg07455279	NDUFA3	0.013	-0.10
cg13899108	PDE4C	5.00 × 10-6	0.10
cg04999691	ZBED6CL	4.92 × 10-5	0.10
cg14597908	GNAS	9.38 × 10-5	0.10
cg21870884	GPR25	9.49 × 10-3	0.11
cg12616277	ESYT3	0.022	0.12
cg12373771	CECR6	3.55 × 10-3	0.12
cg17729667	NINL	4.43 × 10-3	0.13
cg02364642	ARHGEF25	2.33 × 10-3	0.14
cg22449114	TCF15	2.39 × 10-5	0.14
cg03565323	ZNF287	4.52 × 10-3	0.14
cg02388150	SFRP1	1.20 × 10-7	0.15
cg12768605	LO×L2	8.01 × 10-3	0.15
cg25657834	NTSR2	1.46 × 10-4	0.16
cg20914508	GAP43	9.41 × 10-4	0.16
cg10281002	TBX5	1.26 × 10-5	0.17
cg02489552	CCDC105	7.16 × 10-8	0.18
cg05675373	KCNC4	1.82 × 10-6	0.18
cg25148589	GRIA2	6.11 × 10-7	0.18
cg13216057	DKK3	9.64 × 10-4	0.18
cg27092035	ARL10	8.81 × 10-4	0.19
cg12351433	LHCGR	2.20 × 10-6	0.20
cg18573383	KCNC2	5.43 × 10-7	0.21
cg08434234	DGKI	6.60 × 10-5	0.22
cg21096399	MCAM	5.20 × 10-8	0.22
cg10920957	JPH3	1.03 × 10-4	0.25
cg08965235	LTBP3	6.03 × 10-10	0.25
cg27319898	ZNF804B	5.48 × 10-5	0.26
cg26620959	SYNE1	3.89 × 10-6	0.29
cg25070637	SDC2	1.82 × 10-5	0.30
cg07663789	NPR3	6.41 × 10-7	0.31
cg09191327	PRDM12	4.08 × 10-7	0.31
cg06557358	TMEM132E	2.04 × 10-8	0.33
cg10486998	GALR1	2.61 × 10-9	0.36
cg24834740	PPP1R16B	2.23 × 10-9	0.36
cg08090772	ADHFE1	5.19 × 10-11	0.39
cg02217159	KHDRBS2	1.87 × 10-11	0.41

N: Normal; Ad: Adenoma.