Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma

Table 2 Significant DNA methylation alterations of age-related CpG sites in CRC samples compared to normal tissue

cgID	Gene symbol	P value	Δβ (CRC - N)
cg06462291	NT5DC3	3.81 × 10-6	-0.27
cg06144905	PIPOX	1.81 × 10-7	-0.22
cg10345936	SLC36A2	2.49 × 10-5	-0.18
cg13828047	MPI	1.78 × 10-5	-0.17
cg11314684	AKT3	4.55 × 10-5	-0.16
cg00431549	MGP	0.020	-0.12
cg14409958	ENPP2	0.021	-0.11
cg00091693	KRT20	0.010	-0.11
cg17274064	ERG	1.48 × 10-4	-0.11
cg22809047	RPL31	1.91 × 10-3	-0.10
cg00075967	STRA6	0.010	-0.10
cg06952310	NCAN	7.13 × 10-3	-0.10
cg02388150	SFRP1	3.33 × 10-3	0.10
cg03588357	GPR68	7.72 × 10-3	0.10
cg26297688	TMEM263	6.21 × 10-3	0.10
cg04528819	KLF14	0.036	0.10
cg26372517	TFAP2E	9.23 × 10-3	0.11
cg08030082	POMC	1.93 × 10-3	0.11
cg05675373	KCNC4	7.80 × 10-3	0.11
cg10281002	TBX5	0.012	0.11
cg06117855	CLEC3B	1.87 × 10-3	0.11
cg09509673	CCR10	1.91 × 10-4	0.11
cg14597908	GNAS	1.48 × 10-4	0.11
cg27494383	LTK	9.32 × 10-3	0.12
cg21870884	GPR25	5.77 × 10-3	0.13
cg25657834	NTSR2	4.43 × 10-3	0.13
cg22449114	TCF15	3.48 × 10-5	0.13
cg04126866	C10orf99	4.52 × 10-4	0.13
cg25552492	LGI3	9.44 × 10-3	0.14
cg08965235	LTBP3	3.12 × 10-3	0.14
cg06836772	PRKAA2	0.013	0.14
cg02364642	ARHGEF25	1.20 × 10-3	0.16
cg18573383	KCNC2	1.38 × 10-3	0.16
cg12616277	ESYT3	0.015	0.16
cg17729667	NINL	3.46 × 10-3	0.16
cg04999691	ZBED6CL	3.32 × 10-11	0.16
cg12373771	CECR6	3.70 × 10-3	0.17
cg02489552	CCDC105	8.91 × 10-8	0.17
cg25148589	GRIA2	7.77 × 10-6	0.19
cg21096399	MCAM	5.47 × 10-6	0.19
cg20914508	GAP43	4.24 × 10-4	0.20
cg12768605	LYPD5	1.85 × 10-4	0.21
cg13216057	DKK3	2.10 × 10-4	0.21
cg12351433	LHCGR	4.97 × 10-7	0.22
cg08434234	DGKI	5.16 × 10-5	0.23
cg10920957	JPH3	3.00 × 10-4	0.26
cg27092035	ARL10	3.73 × 10-5	0.27
cg06557358	TMEM132E	3.17 × 10-6	0.27
cg26620959	SYNE1	1.32 × 10-6	0.30
cg07663789	NPR3	8.73 × 10-6	0.31
cg09191327	PRDM12	1.79 × 10-6	0.31
cg25070637	SDC2	1.64 × 10-6	0.34
cg10486998	GALR1	1.81 × 10-8	0.35
cg24834740	PPP1R16B	3.56 × 10-12	0.37
cg27319898	ZNF804B	5.41 × 10-8	0.38
cg08090772	ADHFE1	7.18 × 10-14	0.39
cg02217159	KHDRBS2	6.67 × 10-13	0.43

N: Normal; CRC: Colorectal cancer.