Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma

Table 1 Clinical data of samples involved in the high resolution melting study

Sample ID	Age	Gender	Localization	Histology	TNM	Grade	Dukes’ stage (MAC)	Dysplasia	Adenoma size	Sample type
Ch1	4	M	Colon	Normal						FFPE
Ch2	7	F	Cecum	Normal						FFPE
Ch3	11	M	Colon	Normal						FFPE
Ch4	14	M	Transverse	Normal						FFPE
Ch5	5	F	Sigmoid	Normal						FFPE
Ch6	7	F	Descendent	Normal						FFPE
Ch7	1	M	Descendent	Normal						FFPE
Ch8	1	M	Sigmoid	Normal						FFPE
Ch9	10	M	Cecum	Normal						FFPE
Ch10	3	M	Sigmoid	Normal						FFPE
Ch11	17	F	Cecum	Normal						FFPE
Ch12	17	F	Sigmoid	Normal						FFPE
Ch13	16	F	Sigmoid	Normal						FFPE
Ch14	16	F	Cecum	Normal						FFPE
Ch15	1	M	Left colon	Normal						FF
Ch16	3	F	Sigmoid	Normal						FF
Ch17	6	M	Sigmoid	Normal						FF
Ch18	9	M	Sigmoid	Normal						FF
Ch19	17	M	Colon	Normal						FF
N1	44	F	Sigmoid	Normal						FF
N2	31	F	Sigmoid	Normal						FF
N3	59	F	Sigmoid	Normal						FF
N4	54	M	Colon	Normal						FF
N5	68	F	Sigmoid	Normal						FF
N6	71	F	Sigmoid	Normal						FF
N7	69	F	Sigmoid	Normal						FF
N8	57	F	Sigmoid	Normal						FF
AD1	78	M	Asc, sigmoid, rectum	Tubulovillous adenoma				Low-grade	30 mm, 3 mm, 15 mm	FF
AD2	60	M	Sigmoid	Tubular adenoma				Low-grade	6 mm	FF
AD3	88	M	Asc, transv, sigmoid	Tubular adenoma				Low-grade	4 mm, 3 mm, 7-8 mm	FF
AD4	72	F	Rectum	Tubular adenoma				Low-grade	10 mm	FF
AD5	45	F	Descendent	Tubular adenoma				High-grade	5-6 mm	FF
AD6	68	F	Rectum	Tubular adenoma				Low-grade	5 mm	FF
AD7	63	F	Sigmoid	Tubular adenoma				Low-grade	8 mm	FF
AD8	65	F	Asc, transv, rectum	Tubular adenoma				Low-grade	2-3 mm, 2-3 mm, 2-3 mm	FF
AD9	60	F	Sigmoid	Tubular adenoma				Low-grade	5 mm, 4 mm	FF
AD10	77	F	Rectosigmoid	Tubular adenoma				Low-grade	5 mm	FF
AD11	55	F	Asc colon	Tubular adenoma				Low-grade	10 mm	FF
AD12	76	M	Cecum, sigmoid	Tubular adenoma				Low-grade	5 mm, 8-10 mm	FF
AD13	62	F	Sigmoid	Tubular adenoma				High-grade	30 mm	FF
AD14	83	M	Asc colon	Tubulovillous adenoma				High-grade	50-60 mm	FF
AD15	73	M	Cecum, asc, desc	Tubular adenoma				Low-grade	12 mm, 10 mm, 6-8 mm	FF
AD16	64	M	Transv, sigmoid, rectum	Tubular adenoma				Low-grade	5 mm, 25 mm, 15 mm	FF
AD17	63	M	Asc, transv, rectum	Tubular adenoma				Low-grade	2-3 mm, 5 mm, 5-6 mm, 15 mm	FF
AD18	63	F	Sigmoid	Tubulovillous adenoma				Low-grade	25 mm	FF
AD19	63	M	Rectum	Tubulovillous and tubular adenoma				Low-grade	25 mm, 30 mm	FF
AD20	87	M	Sigmoid, rectum	Tubulovillous adenoma				Low-grade	20 mm, 15 mm	FF
AD21	63	F	Sigmoid	Tubulovillous adenoma				Low-grade	25 mm	FF
CRC1	67	F	Sigmoid	Adenocarcinoma	Unknown	Unknown	Unknown			FF
CRC2	76	F	Hepatic flexure	Adenocarcinoma	T2N0M0	2	B1			FF
CRC3	73	F	Sigmoid	Adenocarcinoma	T3N2M1	2	D			FF
CRC4	65	M	Sigmoid	Adenocarcinoma	T2N0M0	1	B1			FF
CRC5	85	F	Cecum	Adenocarcinoma	T2N0M0	2	B1			FF
CRC6	60	M	Hepatic flexure	Adenocarcinoma		unknown	D			FF
CRC7	68	M	Sigmoid, rectum	Adenocarcinoma	T3N0M0	1	B2			FF
CRC8	87	F	Sigmoid	Adenocarcinoma	T3N0M0	2	B2			FF

Ch: Children; N: Normal; Ad: Adenoma; CRC: Colorectal cancer.