Fecal microbial transplant for the treatment of pediatric inflammatory bowel disease

Table 7 Clinical trials of fecal microbial transplant for pediatric inflammatory bowel disease (registered through clinicaltrials.gov)

Location	Trial number	Diagnosis	Age (yr)	Donor	FMT route	Interven-tion	Protocol
Hamilton,	NCT02487238	UC	6-17	Anonymous	Enema	FMT, Saline	Retention enema; 2 × weekly × 6 wk; 33-wk follow up
Canada						Randomized Single Blinded
California, United States	NCT02291523	UC	7-2	Accepting volunteers	Colonoscopic	FMT, Saline	Patients on high-dose 5-ASA; 1 × colonoscopic administration; 12-mo follow up
						Randomized Double Blinded
Chongqing, China	NCT02335281	UC/CD	16-70	Not specified	Nasojejunal	FMT, Mesalazine	Single nasojejunal administration; 1-yr follow up
						Randomized Single Blinded
Texas, United States	NCT01947101	UC	12-20	Anonymous	Colonoscopic /Enema	FMT	Colonoscopic administration for first treatment; subsequent periodic treatments over 1-year with enema administration
Pennsylvania, United States	NCT02108821	UC/CD	2-22	Family member	Colonoscopic	Open Label	Fresh stool sample; 1 ×, 1-h duration; 6-mo follow up
						FMT
Michigan, United States	NCT01560819	UC/CD	7-21	Family member	Enema	Open Label	1-hour retention enema; daily × 5 d; 6-mo follow up
						FMT
Jerusalem, Israel;	NCT02033408	UC/CD	2-75	Not specified	Not specified	Open Label	Secondary treatment for antibiotic, corticosteroid failures; 3-yr follow up
Toronto, Canada;						FMT
Helsinki, Finland;						Open Label
Napoli, Italy;
Rome, Italy;
Krakow, Poland;
Malaga, Spain
Michigan, United States	NCT01560819	UC/CD	7-21	Family member/	Enema	FMT	Retention enema; Administered daily × 5 d; 6-mo follow up
				Chosen by family		Open Label
Turku, Finland	NCT01961492	UC	1-75	Anonymous	Colonoscopic	FMT	Single colonoscopic administration; 1-yr follow up
						Open Label
Jiangsu, China	NCT01793831	UC/CD	10-70	Not specified	Nasogastric	FMT	Single nasogastric administration; 12-mo follow up
Shaanxi, China						Open Label
Jiangsu, China	NCT01790061	UC	10-70	Not specified	Duodenal (gastroscopic)	FMT	1-mo follow up
Shaanxi, China						Open Label	Fresh, or frozen FMT administered via gastroscope
							No prior biologic, immunomodulatory, corticosteroid therapy
Jiangsu, China	NCT02560727	UC	10-70	Not specified	Colonoscopic	Not specified	12-mo follow up
							No prior biologic, immunomodulatory, corticosteroid therapy

UC: Ulcerative colitis; CD: Crohn’s disease.