Fecal microbial transplant for the treatment of pediatric inflammatory bowel disease

Table 4 Published pediatric fecal microbial transplant case series for inflammatory bowel disease

Ref.	AGE (yr)	Diagnosis, n	FMT protocol	Clinical response criteria	Response rate (%)
Kunde et al[32], 2013	7-21	9, UC	Serial enemas for 5 d	Decrease in PUCAI by > 15 points after FMT	7/9 clinical response at 1 wk (78)
					6/9 maintained response at 4 wk (67)
Kellermayer et al[33], 2015	14-16	3, UC	Serial enemas and colonoscopy over 6-12 wk	PUCAI < 35	3/3 endoscopic remission at 2 wk (100)
					3/3 histologic remission at 2 wk (100)
					3/3 clinical response at 4 wk (100)
					3/3 withdrawal of all immunotherapy at 15 wk (100)
Suskind et al[34], 2015	12-19	9, CD	Single FMT	PCDAI < 10	7/9 clinical response at 2 wk (78)
			via NGT		5/9 maintained response at 6, and 12 wk (56)
Suskind et al[35], 2015	13-16	4, UC	Single FMT	PUCAI < 10	No clinical response (0)
			via NGT		No laboratory benefit

FMT: Fecal microbial transplant; PCDAI: Pediatric Crohn’s Disease Activity Index; NGT: Nasogastric tube.