Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases

doi:10.3748/wjg.v22.i47.10275

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 21, 2016; 22(47): 10275-10286
Published online Dec 21, 2016. doi: 10.3748/wjg.v22.i47.10275

Table 3 Serine protease inhibitors investigated in experimental visceral hypersensitivity models

Inhibitor name	Target(s)	Ref.
Aprotinin	Chymotrypsin, elastase, KLK, plasmin, PA, trypsin, urokinase, XIIa	[49]
Bowman-Birk inhibitor	Chymotrypsin, trypsin	[70,71]
Camostat mesilate (FOY-305)	Trypsin, matriptase, prostasin, plasmin, tPA, uPA, Xa, IXa, thrombin, tissue factor, complement factors, tryptase, HNE, KLK	[68,69]
Cathepsin-G inhibitor	Cathepsin G	[49]
Nafamostat mesilate (FUT-175)	Tryptase, trypsin, C1r, C1s, thrombin, kallikrein, plasmin	[37,65-67]
UAMC-0050	Tryptase, matriptase, KLK4, KLK8, uPA	[66,67,93]
Soybean trypsin inhibitor (SBTI)	Trypsin, chymotrypsin, plasmin, kallikrein, Xa	[49]

C1r: Complement component 1r; C1s: Complement component 1s; HNE: 4-hydoxynonenal; KLK: Kallikrein; PA: Plasminogen activator; tPA: Tissue plasminogen activator; uPA: Urokinase plasminogen activator.

Citation: Ceuleers H, Van Spaendonk H, Hanning N, Heirbaut J, Lambeir AM, Joossens J, Augustyns K, De Man JG, De Meester I, De Winter BY. Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases. World J Gastroenterol 2016; 22(47): 10275-10286
URL: https://www.wjgnet.com/1007-9327/full/v22/i47/10275.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i47.10275